MOTS-c and insulin sensitivity: the original mouse study
Evidence level: Cell and animal research · Publication year: 2015
This overview discusses one original scientific publication on MOTS-c. The source is included in PubMed, the literature database of the U.S. National Library of Medicine.
What was studied?
This original publication described MOTS-c as a mitochondrially encoded peptide and investigated effects on metabolism and insulin sensitivity in preclinical models.
What did the researchers find?
The researchers reported changes in metabolic signaling pathways and improved insulin sensitivity in mice. In a high-fat diet model, changes in weight gain were also found.
What are the limitations?
The results in mice cannot be translated into expectations for human weight loss or diabetes treatment. The study does not establish a clinical administration regimen.
Significance for research
The publication is relevant as a starting point for the experimental MOTS-c literature, with a clear preclinical scope.
Official source
Original publication via PubMed — PMID 25738459 · DOI: 10.1016/j.cmet.2015.02.009
Research Use Only. This literature summary contains no treatment or usage advice. Research on a molecule is not evidence of the efficacy, safety, or purity of a Peptidera product. PubMed indexing is not product approval.
Related research products
View product specifications and available batch documentation. The studies discussed were not conducted using Peptidera products and do not prove the efficacy of our products. For laboratory research only; not for human or animal consumption.