5-Amino-1MQ and NNMT inhibition: the original mouse study
Evidence level: Cell and animal research
Research question
What happens when the NNMT enzyme is inhibited with a small molecule? 5-Amino-1MQ is a research compound, not a peptide.
Research model
The researchers investigated enzyme selectivity and membrane penetration of inhibitors. They then studied 5-Amino-1MQ in mice with diet-induced obesity.
What was found?
The study reported reductions in body weight, adipose tissue mass, fat cell size, and total plasma cholesterol in the mouse model studied.
Limitations and interpretation
This was a short preclinical proof-of-concept study. These results do not establish proven efficacy or safety in humans. Selectivity in an enzyme assay is also not a complete safety assessment.
Original publication
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. PMID: 29155147. View the original publication on PubMed.
This summary is based on the available source description and abstract; it is not a complete systematic review.
All Peptidera products are intended exclusively for scientific research and laboratory use. Not for human or animal consumption, self-administration, diagnosis, or treatment.
Related research products
View product specifications and available batch documentation. The studies discussed were not conducted with Peptidera products and do not establish the efficacy of our products. For laboratory research only; not for human or animal consumption.