MOTS-c in the cell nucleus: gene expression during metabolic stress
Evidence level: Mechanistic cell research · Publication year: 2018
This overview discusses one original scientific publication on MOTS-c. The source is indexed in PubMed, the literature database of the U.S. National Library of Medicine.
What was investigated?
Researchers investigated whether the mitochondrially encoded peptide MOTS-c moves to the cell nucleus under metabolic stress and is involved there in the regulation of gene expression.
What did the researchers find?
In the models used, MOTS-c moved to the nucleus in an AMPK-dependent manner. The results linked this translocation to changes in stress-related gene expression.
What are the limitations?
The experiment describes a mechanism in cells. It does not establish the clinical efficacy or safety of administered MOTS-c in humans.
Significance for research
The study provides a concrete basis for research into communication between mitochondria and the cell nucleus.
Official source
Original publication via PubMed — PMID 29983246 · DOI: 10.1016/j.cmet.2018.06.008
Research Use Only. This literature summary does not contain treatment or usage advice. Research on a molecule is not evidence of the efficacy, safety, or purity of a Peptidera product. PubMed indexing is not product approval.
Related research products
View product specifications and available batch documentation. The studies discussed were not conducted with Peptidera products and do not prove the efficacy of our products. For laboratory research only; not for human or animal consumption.