SS-31 and mitochondrial proteins: an interaction map
Evidence level: Mechanistic research using crosslinking and mass spectrometry · Publication year: 2020
This overview discusses one original scientific publication on SS-31. The source is indexed in PubMed, the literature database of the U.S. National Library of Medicine.
What was studied?
Researchers used a labeled SS-31 variant to identify interactions with mitochondrial proteins. This allowed them to investigate which molecular environment alongside cardiolipin is involved with the peptide.
What did the researchers find?
The analysis identified interactions with multiple proteins involved in energy transfer and mitochondrial metabolism. Some binding regions were located near known cardiolipin-protein interactions.
What are the limitations?
An interaction map does not prove that every identified binding has a therapeutic effect. A labeled variant and isolated mitochondrial systems are research tools, not clinical endpoints.
Significance for research
The study expands the mechanistic SS-31 literature with measurable protein contacts.
Official source
Original publication via PubMed — PMID 32554501 · DOI: 10.1073/pnas.2002250117
Research Use Only. This literature summary does not contain treatment or usage advice. Research on a molecule is not evidence of the efficacy, safety, or purity of a Peptidera product. PubMed indexing is not product approval.
Related research products
View product specifications and available batch documentation. The studies discussed were not conducted with Peptidera products and do not demonstrate the efficacy of our products. For laboratory research only; not for human or animal consumption.