Elamipretide and ATP production: randomized study in older adults

Evidence level: Human randomized study

Research question

Can elamipretide change measured mitochondrial ATP production capacity in older skeletal muscle in the short term?

Study design

In a double-blind, placebo-controlled study, older adults received the clinical investigational formulation of elamipretide or placebo. The researchers measured ATP production capacity in skeletal muscle.

What was found?

After the single investigational intervention, an improvement in measured ATP production capacity was reported compared with placebo.

Limitations and interpretation

ATP production capacity is a physiological measurement outcome. A short-term change does not prove longer lifespan or lasting improvement in functioning. The clinical formulation and medical research context must not be equated with an RUO vial.

Original publication

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. PMID: 34264994. View the original publication on PubMed.

This summary is based on the available source description and abstract; it is not a complete systematic review.

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